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November 30, 2023
Original Investigation

A Learning Program for Treatment Recommendations by Molecular Tumor Boards and Artificial Intelligence

Abstract Full Text
open access
JAMA Oncol. Published online November 30, 2023. doi:10.1001/jamaoncol.2023.5120

This quality improvement study examines the effectiveness of a learning program for molecular tumor boards to share best practices for providing optimal treatment recommendations in 50 identical simulated cases of advanced cancer.

Research Letter

Contemporary Trends in Reviewing Test Results Through the Electronic Patient Portal Among Patients With Cancer

Abstract Full Text
JAMA Oncol. Published online November 30, 2023. doi:10.1001/jamaoncol.2023.5047

This cohort study among patients with cancer examines changes in the time from posting of test results in the electronic health record to patient viewing in the patient portal before and after implementation of the 21st Century Cures Act.

Review

Structural Racism and Lung Cancer Risk: A Scoping Review

Abstract Full Text
has active quiz
JAMA Oncol. Published online November 30, 2023. doi:10.1001/jamaoncol.2023.4897

This review examines the association of structural racism with lung cancer risk among racial and ethnic minority groups.

Poetry and Oncology

Peaches

Abstract Full Text
JAMA Oncol. Published online November 30, 2023. doi:10.1001/jamaoncol.2023.5050
November 22, 2023
Original Investigation

Clinical and Biomarker Findings of Neoadjuvant Pembrolizumab and Carboplatin Plus Docetaxel in Triple-Negative Breast Cancer: NeoPACT Phase 2 Clinical Trial

Abstract Full Text
JAMA Oncol. Published online November 22, 2023. doi:10.1001/jamaoncol.2023.5033

This open-label phase 2 randomized clinical trial evaluates the clinical effects and biomarker findings of treatment with neoadjuvant pembrolizumab and carboplatin plus docetaxel in patients with triple-negative breast cancer.

First-Line Osimertinib for Previously Untreated Patients With NSCLC and Uncommon EGFR Mutations: The UNICORN Phase 2 Nonrandomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online November 22, 2023. doi:10.1001/jamaoncol.2023.5013

This nonrandomized phase 2 clinical trial assesses the usefulness of osimertinib in previously untreated patients with metastatic non–small cell lung cancer (NSCLC) harboring uncommon EGFR mutations, excluding exon 20 insertion mutations.

Research Letter

Mortality and Hospitalization Risks in Patients With Cancer and the SARS-CoV-2 Omicron Variant

Abstract Full Text
JAMA Oncol. Published online November 22, 2023. doi:10.1001/jamaoncol.2023.5042

This cohort study compares the mortality and hospitalization risks among patients with vs without solid cancer and diagnosed with COVID-19 during the period when the Omicron variant was dominant.

Viewpoint

Expanding Access to High-Quality Cancer Care Through Policy—California Cancer Care Equity Act

Abstract Full Text
JAMA Oncol. Published online November 22, 2023. doi:10.1001/jamaoncol.2023.5010

This Viewpoint describes key domains in which the California Cancer Care Equity Act may benefit patients, recommends potential improvements to further expand access and reduce disparities, and suggests possible safeguards to monitor and minimize unintended consequences.

Invited Commentary

Osimertinib in Patients With Non–Small Cell Lung Cancer and Uncommon EGFR Mutations—Chasing Unicorns?

Abstract Full Text
JAMA Oncol. Published online November 22, 2023. doi:10.1001/jamaoncol.2023.5004
Comment & Response

Assessing Response for Nivolumab Plus Ipilimumab in Squamous Cell Carcinoma of the Head and Neck

Abstract Full Text
JAMA Oncol. Published online November 22, 2023. doi:10.1001/jamaoncol.2023.5401

Assessing Response for Nivolumab Plus Ipilimumab in Squamous Cell Carcinoma of the Head and Neck

Abstract Full Text
JAMA Oncol. Published online November 22, 2023. doi:10.1001/jamaoncol.2023.5404

Assessing Response for Nivolumab Plus Ipilimumab in Squamous Cell Carcinoma of the Head and Neck—Reply

Abstract Full Text
JAMA Oncol. Published online November 22, 2023. doi:10.1001/jamaoncol.2023.5407
November 16, 2023
Original Investigation

Incidence of Recurrence and Time to Recurrence in Stage I to III Colorectal Cancer: A Nationwide Danish Cohort Study

Abstract Full Text
open access
JAMA Oncol. Published online November 16, 2023. doi:10.1001/jamaoncol.2023.5098

This cohort study investigates stage-specific rates and timing of colorectal cancer recurrence using data from Danish national health registries from 2004 to 2019.

Nivolumab for Patients With High-Risk Oral Leukoplakia: A Nonrandomized Controlled Trial

Abstract Full Text
open access
JAMA Oncol. Published online November 16, 2023. doi:10.1001/jamaoncol.2023.4853

This nonrandomized controlled trial assesses the safety and clinical activity of anti–PD-1 therapy to treat high-risk proliferative verrucous leukoplakia.

Cost Savings and Waste Reduction Through Redispensing Unused Oral Anticancer Drugs: The ROAD Study

Abstract Full Text
JAMA Oncol. Published online November 16, 2023. doi:10.1001/jamaoncol.2023.4865

This multicenter intervention study conducted at 4 hospital pharmacies in the Netherlands assessed waste reduction and net cost savings attained by redispensing leftover oral anticancer drugs compared with the standard practice of disposal.

Research Letter

Distribution of Cancer Care Resources Across US Hospitals by Patient Race and Ethnicity

Abstract Full Text
JAMA Oncol. Published online November 16, 2023. doi:10.1001/jamaoncol.2023.4952

This cross-sectional study assesses the availability of cancer-related services in hospitals with predominantly racial and ethnic minority patient populations.

Editorial

Moving Toward Personalized Colorectal Cancer Follow-Up Care

Abstract Full Text
JAMA Oncol. Published online November 16, 2023. doi:10.1001/jamaoncol.2023.5072
Invited Commentary

Immunotherapy in Prepatients—Preventing or Promoting a Malignant Transformation?

Abstract Full Text
JAMA Oncol. Published online November 16, 2023. doi:10.1001/jamaoncol.2023.4799
JAMA Oncology Patient Page

Malignant Pericardial Effusion, or Fluid Around the Heart Due to Cancer

Abstract Full Text
free access
JAMA Oncol. Published online November 16, 2023. doi:10.1001/jamaoncol.2023.4500

This JAMA Oncology Patient Page describes the accumulation of excess fluid around the heart caused by cancer, known as malignant pericardial effusion.

November 9, 2023
Original Investigation

Global Stage Distribution of Breast Cancer at Diagnosis: A Systematic Review and Meta-Analysis

Abstract Full Text
JAMA Oncol. Published online November 9, 2023. doi:10.1001/jamaoncol.2023.4837

This systematic review with meta-analysis examines the global distribution of breast cancer stage by country, age group, calendar period, and socioeconomic status using population-based data.

Practice Patterns for Organ Preservation in US Patients With Rectal Cancer, 2006-2020

Abstract Full Text
JAMA Oncol. Published online November 9, 2023. doi:10.1001/jamaoncol.2023.4845

This case series describes organ preservation trends among patients with rectal cancer in the US from 2006 to 2020.

Brief Report

Assessment of Changes in Cancer Treatment During the First Year of the COVID-19 Pandemic in the US

Abstract Full Text
JAMA Oncol. Published online November 9, 2023. doi:10.1001/jamaoncol.2023.4513

This cohort study examines changes in cancer diagnoses and treatment in the US during the first year of the COVID-19 pandemic.

Research Letter

Outcomes in Patients With Postchemotherapy Residual Nonretroperitoneal Disease in Nonseminomatous Germ Cell Tumors

Abstract Full Text
JAMA Oncol. Published online November 9, 2023. doi:10.1001/jamaoncol.2023.4949

This case-control study assesses the association between teratoma in the primary tumor or postchemotherapy resections and survival outcomes.

Review

Implications of High Tumor Burden on Chimeric Antigen Receptor T-Cell Immunotherapy: A Review

Abstract Full Text
has active quiz
JAMA Oncol. Published online November 9, 2023. doi:10.1001/jamaoncol.2023.4504

This review examines how high tumor burden and tumor-burdened immune system dysfunction play central roles in the efficacy and safety of CAR T-cell therapy.

Comment & Response

Bacterial Decolonization for Prevention of Radiation Dermatitis—Fragility Index Analysis

Abstract Full Text
JAMA Oncol. Published online November 9, 2023. doi:10.1001/jamaoncol.2023.5007
November 4, 2023
Original Investigation

Diagnostic Outcomes of Concurrent DNA and RNA Sequencing in Individuals Undergoing Hereditary Cancer Testing

Abstract Full Text
open access
JAMA Oncol. Published online November 4, 2023. doi:10.1001/jamaoncol.2023.5586

This diagnostic study assesses the outcomes of paired DNA and RNA testing on detection of disease-causing germline genetic variants and resolution of variants of uncertain significance.

November 2, 2023
Original Investigation

Breast Cancer Incidence After a False-Positive Mammography Result

Abstract Full Text
open access
JAMA Oncol. Published online November 2, 2023. doi:10.1001/jamaoncol.2023.4519

This Swedish cohort study examines long-term outcomes after a false-positive mammography result and investigates whether the association of a false-positive mammography result with cancer differs by baseline characteristics, tumor characteristics, and time since the false-positive result.

Brief Report

Vaginal Estrogen Therapy Use and Survival in Females With Breast Cancer

Abstract Full Text
JAMA Oncol. Published online November 2, 2023. doi:10.1001/jamaoncol.2023.4508

This cohort study compares the mortality risk associated with vaginal estrogen therapy vs no hormone replacement therapy in 2 cohorts of patients with breast cancer in Scotland and Wales.

Research Letter

Exclusion of Ranitidine From Premedication Regimens During Paclitaxel Treatment

Abstract Full Text
JAMA Oncol. Published online November 2, 2023. doi:10.1001/jamaoncol.2023.4821

This cohort study conducted in the Netherlands uses electronic medical records to assess incidence of hypersensitivity reactions with and without H2-receptor agonist premedication before paclitaxel administration.

Viewpoint

Derailing Carcinogens—Oncologists and the Ohio Train Derailment

Abstract Full Text
JAMA Oncol. Published online November 2, 2023. doi:10.1001/jamaoncol.2023.4817

This Viewpoint discusses how oncologists can support environmental strategies to reduce dependence on petrochemicals, which are associated with cancer risk.

Comment & Response

Racial Disparities and Survival Outcomes in Breast Cancer

Abstract Full Text
JAMA Oncol. Published online November 2, 2023. doi:10.1001/jamaoncol.2023.4828

Racial Disparities and Survival Outcomes in Breast Cancer—Reply

Abstract Full Text
JAMA Oncol. Published online November 2, 2023. doi:10.1001/jamaoncol.2023.4831
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