Antonio Terracciano, PhD; Martina Luchetti, PhD; Selin Karakose, PhD; et al.
open access
JAMA Neurol. 2023;80(11):1138-1144. doi:10.1001/jamaneurol.2023.3382
This cohort study uses data from the UK Biobank to assess the association of loneliness with the risk of incident Parkinson disease.
Jacqueline A. French, MD; Roger J. Porter, MD; Emilio Perucca, MD, PhD; et al.
open access
JAMA Neurol. 2023;80(11):1145-1154. doi:10.1001/jamaneurol.2023.3542
This randomized clinical trial evaluates the efficacy and safety of XEN1101, a potassium channel opener, in the treatment of adults with intractable focal-onset seizures.
Shubham Misra, PhD; Scott E. Kasner, MD; Jesse Dawson, MD; et al.
JAMA Neurol. 2023;80(11):1155-1165. doi:10.1001/jamaneurol.2023.3240
This systematic review and meta-analysis investigates the association of mortality, poor functional outcomes, recurrent stroke, and dementia in patients with poststroke seizures compared with patients without poststroke seizures.
Gil D. Rabinovici, MD; Maria C. Carrillo, PhD; Charles Apgar, MBA; et al.
JAMA Neurol. 2023;80(11):1166-1173. doi:10.1001/jamaneurol.2023.3490
This nonrandomized controlled trial compares rates of inpatient hospitalizations and emergency department visits between Medicare beneficiaries with cognitive decline who participated in the Imaging Dementia–Evidence for Amyloid Scanning study vs Medicare beneficiaries who had not undergone amyloid positron emission tomography.
Emanuele Cerulli Irelli, MD, PhD; Enrico Cocchi, MD, PhD; Alessandra Morano, MD, PhD; et al.
JAMA Neurol. 2023;80(11):1174-1181. doi:10.1001/jamaneurol.2023.3400
This comparative effectiveness study investigates the comparative effectiveness of levetiracetam and lamotrigine as initial antiseizure medication in female patients of childbearing age with idiopathic generalized epilepsy.
Juan Carlos Martinez-Gutierrez, MD; Youngran Kim, PhD; Sergio Salazar-Marioni, MD; et al.
open access
JAMA Neurol. 2023;80(11):1182-1190. doi:10.1001/jamaneurol.2023.3206
This study attempts to determine whether automated computed tomography angiogram interpretation coupled with secure group messaging can improve in-hospital endovascular stroke therapy workflows.
Hannah A. Jin; Corey T. McMillan, PhD; Isabel Yannatos, BS; et al.
JAMA Neurol. 2023;80(11):1191-1198. doi:10.1001/jamaneurol.2023.3093
This cross-sectional study explores racial disparities in dementia severity, functional impairment, and neuropsychiatric symptoms in individuals with a diagnosis of frontotemporal dementia.
Philippa C. Lavallée, MD; Hugo Charles, BST; Gregory W. Albers, MD; et al.
JAMA Neurol. 2023;80(11):1199-1208. doi:10.1001/jamaneurol.2023.3344
This cohort study assesses the extent of coexistence between underlying pathology in patients with transient ischemic attack and minor ischemic stroke, their 5-year risk of major vascular events, and factors associated with risk with the benefit of the more recently adopted ASCOD classification system.
Raquel N. Taddei, MD; Romain Perbet, MD, PhD; Anastasie Mate de Gerando, PhD; et al.
JAMA Neurol. 2023;80(11):1209-1221. doi:10.1001/jamaneurol.2023.3530
This cross-sectional study assesses whether synapses containing tau oligomers are excessively eliminated by microglia and astrocytes in brains of individuals with vs without dementia but similar neuropathologic changes at autopsy suggestive of early clinical stages of Alzheimer disease.
Alessandro Salvalaggio, MD, PhD; Lorenzo Pini, PhD; Matteo Gaiola, MD; et al.
JAMA Neurol. 2023;80(11):1222-1231. doi:10.1001/jamaneurol.2023.3284
This prognostic study examines the use of a white matter tract density index in the prediction of overall survival in patients with glioblastoma.