New Online

This Viewpoint discusses the inclusion of pregnant patients in clinical trials for antiseizure medication.

This secondary analysis of the ANGEL-ASPECT randomized clinical trial examines outcomes of endovascular therapy vs medical management across varying Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and infarct core volume strata in patients with large infarct.

This cohort study assesses the occurrence of progression independent of relapse activity and relapse-associated worsening in pediatric and adult patients with multiple sclerosis.

A 31-year-old woman was seen with contractures in her fingers and toes, carpal inversion, dysarthria, dysphagia, hypertonia, decreased tendon reflexes, absence of Babinski sign, and no psychiatric problems and significant global atrophy. What is your diagnosis?

This cross-sectional study compares price data for ocrelizumab and rituximab to estimate the savings to Medicare and Medicaid if rituximab were used in the treatment of multiple sclerosis instead of the higher-priced ocrelizumab.

This Viewpoint addresses the challenges of prior authorization: decreased access, delayed care, decreased patient satisfaction and outcomes, and increased clinician burnout.

This On the Brain describes a Hmong student’s experience in medical school.

This cohort study examines the association of fetal exposure to antiseizure medications with subsequent adaptive, behavioral or emotional, and neurodevelopmental disorder outcomes at 2, 3, and 4.5 years of age.

This case report describes reversible cortical and basal ganglia lesions in late-onset methylmalonic aciduria in a man in his mid-40s.

This study addresses inconsistent results from studies of suicidal ideation and behavior in patients with Parkinson PD.

This pragmatic trial evaluates whether palliative care training for neurologists and remote access to a palliative care team can improve outcomes in patients with Parkinson disease and related disorders in community settings.

This case report describes how neuroimaging was used to determine treatment for episodic sudden-onset weakness and numbness in the left limbs.

This randomized clinical trial examines data for patients with Alzheimer dementia to determine whether brexpiprazole is an efficacious, safe, and well-tolerated treatment for agitation.

This genetic association study assesses associations between apolipoprotein E and Alzheimer disease risk across age, sex, race and ethnicity, and global population ancestry.

This cohort study evaluates amyloid-related tau spreading in apolipoprotein E ε4 carriers and amyloid positron emission tomography thresholds at which tau spreading may accelerate.

This cohort study investigates the timing of neuroaxonal pathology in individuals with multiple sclerosis who experience disability worsening.